This study integrates research on knowledge-intensive entrepreneurship and sustainable entrepreneurship in the light of new ventures’ increasing need to consider the social and environmental impact of their knowledge-intensive activities. We reviewed 49 articles with the twofold aim of exploring how knowledge-intensive and sustainable new ventures interact with the actors embedded in the entrepreneurial ecosystem to (1) pursue elements of survival and growth, and to (2) contribute to economic growth and sustainable development. In the conclusion of our article, we introduce a research agenda to identify relevant avenues for future studies.